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PD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, also inhibiting Src activity with IC50 of 22 nM.
GNF-5 is a selective and allosteric Bcr-Abl inhibitor with IC50 of 220 nM.
BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. Phase 1.
Imatinib Mesylate (STI571) is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl . c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.
Features: Dual Bcr-Abl/Lyn inhibitor.
Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl . PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.
Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT).
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DCC-2036 (Rebastinib) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.
Features: A conformational control inhibitor of Abl1 and T315I Abl1.
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl . shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells.
GZD824 Dimesylate is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
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you are using Nolvadex to reduce your risk of breast cancer and you have a history of blood clots in the lung or leg
you are using Nolvadex to reduce your risk of breast cancer and you also take certain anticoagulants (eg, warfarin)
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Chemical Information
Related Estrogen/progestogen Receptor Products
Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM) . used for the treatment of dyspareunia.
Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM.
Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.
Raloxifene is an estrogen antagonist, which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.
Features: Raloxifene is as effective as tamoxifen in reducing the incidence of breast cancer in postmenopausal women at increased risk.
Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.
Features: Mifepristone is the first approved medication for patients with endogenous cushing`s syndrome.
LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
Features: Demonstrates significantly higher binding activity toward ERβ than ERα.
Clomifene citrate is a selective estrogen receptor modulator.
Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
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